Automated discovery and optimization of large irregular tensegrity structures

Tensegrities consist of disjoint struts connected by tensile strings which maintain shape due to pre-stress stability. Because of their rigidity, foldability and deployability, tensegrities are becoming increasingly popular in engineering. Unfortunately few effective analytical methods for discovering tensegrity geometries exist. We introduce an evolutionary algorithm which produces large tensegrity structures, and demonstrate its efficacy and scalability relative to previous methods. A generative representation allows the discovery of underlying structural patterns. These techniques have produced the largest and most complex irregular tensegrities known in the field, paving the way toward novel solutions ranging from space antennas to soft robotics.     

Generalised Procrustes Analysis with optimal scaling: Exploring data from a power supplier

Generalised Procrustes Analysis (GPA) is a method for matching several, possibly large, data sets by fitting them to each other using transformations, typically rotations. The linear version of GPA has been applied in a wide range of contexts. A non-linear extension of GPA is developed which uses Optimal Scaling (OS). The approach is suited to match data sets that contain nominal variables. A database of a Dutch power supplier that contains many categorical variables unfit for the usual linear GPA methodology is used to illustrate the approach.     

Ultrathin Films of Single‐Walled Carbon Nanotubes for Electronics and Sensors: A Review of Fundamental and Applied Aspects

Ultrathin films of single‐walled carbon nanotubes (SWNTs) represent an attractive, emerging class of material, with properties that can approach the exceptional electrical, mechanical, and optical characteristics of individual SWNTs, in a format that, unlike isolated tubes, is readily suitable for scalable integration into devices. These features suggest the potential for realistic applications as conducting or semiconducting layers in diverse types of electronic, optoelectronic and sensor systems. This article reviews recent advances in assembly techniques for forming such films, modeling and experimental work that reveals their collective properties, and engineering aspects of implementation in sensors and in electronic devices and circuits with various levels of complexity. A concluding discussion provides some perspectives on possibilities for future work in fundamental and applied aspects.     

In situ observation of tensile deformation of high-pressure die-cast specimens of AM50 alloy

In situ observation of HPDC AM50 alloy in the SEM chamber was performed to study the changes of the micro-voids and the β phase during tensile deformation. The results suggested that micro-voids had little change in the elastic region, opened linearly with increasing load in the plastic region and led to final fracture. The detachment of β phase from the interface was also observed in the plastic region and there was no evidence to suggest that the detachment led to the final fracture.     

Triphasic ceramic coated hydroxyapatite as a niche for goat stem cell-derived osteoblasts for bone regeneration and repair

Current treatment strategies for the repair or replacement of bone use synthetic implants with stem cells and their progeny––a new approach to address unmet medical needs. This study has evaluated the effect of a silica-coated bioactive ceramic, namely HASi in comparison to hydroxyapatite (HA) on the adhesion, proliferation and osteogenic differentiation of goat bone marrow-derived mesenchymal stem cells in vitro in a prolonged culture of 28 days. The cellular activities were significantly enhanced on HASi signifying the role of silica to stimulate osteoblast cells. The fabrication of such a ‘cell-ceramic construct using autologous MSCs’ is aimed for the transplantation to a large bone defect site in the goat femur model which still remains a formidable challenge in Orthopedic surgery.     

The social costs of emotional suppression: A prospective study of the transition to college.

There is growing interest in understanding how emotion regulation affects adaptation. The present study examined expressive suppression (which involves inhibiting the overt expression of emotion) and how it affects a critical domain of adaptation, social functioning. This investigation focused on the transition to college, a time that presents a variety of emotional and social challenges. Analyses focused on 2 components of suppression: a stable component, representing individual differences expressed both before and after the transition, and a dynamic component, representing variance specific to the new college context. Both components of suppression predicted lower social support, less closeness to others, and lower social satisfaction. These findings were robustly corroborated across weekly experience reports, self-reports, and peer reports and are consistent with a theoretical framework that defines emotion regulation as a dynamic process shaped by both stable person factors and environmental demands. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Processes and outcomes of psychotherapists' personal therapy: Replication and extension 20 years later.

In this replication and extension of a national survey of psychotherapists conducted in 1987, American psychologists (n = 219), counselors (n = 191), and social workers (n = 192) reported in 2007 on the processes and outcomes of their personal therapy experiences. Of the 85% who sought therapy at least once, women, men, and members of all three professions were equally as likely to have received personal treatment. Their top reasons for seeking therapy were marital–couple distress (20%), depression (13%), need for self-understanding (12%), and anxiety–stress (10%). Approximately 24% used psychotropic medication in combination with personal therapy. More than 90% of therapists reported positive outcomes across multiple domains. The modal lasting lessons from personal treatment related to therapist reliability, skill, and empathy. The results are tentatively compared with those obtained in 1987, thus chronicling the evolution of personal therapy among psychologists and social workers during the past 20 years. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Using comparison data to differentiate categorical and dimensional data by examining factor score distributions: Resolving the mode problem.

Factor-analytic research is common in the study of constructs and measures in psychological assessment. Latent factors can represent traits as continuous underlying dimensions or as discrete categories. When examining the distributions of estimated scores on latent factors, one would expect unimodal distributions for dimensional data and bimodal or multimodal distributions for categorical data. Unfortunately, identifying modes is subjective, and the operationalization of counting local maxima has not performed very well. Rather than locating and counting modes, the authors propose performing parallel analyses of categorical and dimensional comparison data and calculating an index of the relative fit of these competing structural models. In an extensive Monte Carlo study, the authors replicated prior results for mode counting and found that trimming distributions' tails helped. However, parallel analyses of comparison data achieved much greater accuracy, improved base rate estimation, and afforded consistency checks with other taxometric procedures. Two additional studies apply this approach to empirical data either known to be categorical or presumed to be dimensional. Each study supports this new method for factor-analytic research on the latent structure of constructs and measures in psychological assessment. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A preliminary pharmacogenetic investigation of adverse events from topiramate in heavy drinkers.

Topiramate, an anticonvulsant medication, is an efficacious treatment for alcohol dependence. To date, little is known about genetic moderators of side effects from topiramate. The objective of this study was to examine 3 single nucleotide polymorphisms (SNPs) of the glutamate receptor GluR5 gene (GRIK1) as predictors of topiramate-induced side effects in the context of a laboratory study of topiramate. Heavy drinkers (n = 51, 19 women and 32 men), 75% of whom met criteria for an alcohol use disorder, completed a 5-week dose escalation schedule to a target dose of either 200 or 300 mg or matched placebo. The combined medication groups were compared with placebo-treated individuals for side effects at target dose. Analyses revealed that an SNP in intron 9 of the GRIK1 gene (rs2832407) was associated with the severity of topiramate-induced side effects and with serum levels of topiramate. Genes underlying glutamatergic neurotransmission, such as the GRIK1 gene, may help predict heterogeneity in topiramate-induced side effects. Future studies in larger samples are needed to more fully establish these preliminary findings. (PsycINFO Database Record (c) 2010 APA, all rights reserved)